Her heart ached with loneliness.

Meaning: This means that she was feeling a lot of pain and discomfort because she was feeling alone and isolated.

Choice of Words: Ached means to feel pain or discomfort. Loneliness means the feeling of being alone or isolated. When you put them together, "heart ached with loneliness" means to feel pain or discomfort because of feeling alone or isolated.

Alternative Expressions

Related Expressions