I eat them at least once a week.
Meaning: This sentence describes the frequency of eating pizza and hotdogs.
Choice of Words: Eat means to put food in your mouth and swallow it. Them refers to pizza and hotdogs. Once means one time. A is used before singular nouns. Week is a period of seven days. When you put them together, "I eat them at least once a week" means you consume pizza and hotdogs regularly, at least one time during each seven-day period.
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Related Expressions